![]() ![]() "Our multidisciplinary team is poised to tackle the challenges posed by coronaviruses head on,” said Dr. The team will then develop vaccines that offer broad protection against existing and future SARS-CoV-2 variants, as well as pandemic, zoonotic (those that can jump from animals to humans), and seasonal coronaviruses responsible for other illnesses. PLUTO researchers will figure out what makes our immune response strong and long-lasting against coronaviruses. The “Programming Long-lasting Immunity to Coronaviruses” (PLUTO) project will be led by Viviana Simon, MD, PhD, Professor of Microbiology Pathology, Molecular and Cell-Based Medicine and Medicine (Infectious Diseases) at the Icahn School of Medicine at Mount Sinai, and Ali Ellebedy, PhD, Associate Professor of Pathology and Immunology, Medicine and Molecular Microbiology at Washington University School of Medicine in St. While considerable progress has been made to develop interventions (i.e., monoclonal antibodies, antivirals, vaccines) to treat and prevent COVID-19, the continued emergence of viral variants with increased transmissibility and resistance to antibody neutralization highlights the urgent need for continued research into the correlates of long-lasting immune protection to design the next generation of pan-coronavirus (universal coronavirus) vaccines. The COVID-19 pandemic, caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has infected 280 million people and caused more than five million deaths worldwide since late 2019. ![]() The National Institute of Allergy and Infectious Diseases has awarded the Icahn School of Medicine at Mount Sinai a five-year, $13 million grant to bring together experts from multiple disciplines across five research institutions to create better vaccines against current as well as emerging coronaviruses. ![]()
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